Cardioprotection by remote ischemic conditioning: Mechanisms and clinical evidences
نویسندگان
چکیده
منابع مشابه
Neurogenic pathways in remote ischemic preconditioning induced cardioprotection: Evidences and possible mechanisms
Remote ischemic preconditioning (RIPC) is an intrinsic phenomenon whereby 3~4 consecutive ischemia-reperfusion cycles to a remote tissue (noncardiac) increases the tolerance of the myocardium to sustained ischemiareperfusion induced injury. Remote ischemic preconditioning induces the local release of chemical mediators which activate the sensory nerve endings to convey signals to the brain. The...
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Aetna considers remote ischemic conditioning experimental and investigational for the treatment of aneurysmal subarachnoid hemorrhage, myocardial infarction, primary graft dysfunction following lung transplantation, spinal cord injury, traumatic brain injury, and other indications (e.g., for cardiac, cognitive, pulmonary and renal protection during cardiac surgery, endovascular aneurysm repair,...
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Brief episodes of ischaemia/reperfusion in peripheral organs or limbs render the heart and other parenchymal organs more resistant to subsequent injury by more prolonged periods of ischaemia and reperfusion. Such remote ischaemic conditioning (RIC) has not only been demonstrated in experimental animals, but is also operative in humans. In proof-of-concept studies, RIC reduced infarct size in pa...
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Persistent myocardial ischaemia causes cell death if not rescued by early reperfusion. Millions of years in nature's laboratory have evolved protective responses that 'condition' the heart (and other tissues) to adapt to stressors, and these responses are applicable to the relatively new societal stress of myocardial ischaemia and reperfusion injury. Conditioning can be applied before (precondi...
متن کاملRemote ischemic conditioning.
In remote ischemic conditioning (RIC), brief, reversible episodes of ischemia with reperfusion in one vascular bed, tissue, or organ confer a global protective phenotype and render remote tissues and organs resistant to ischemia/reperfusion injury. The peripheral stimulus can be chemical, mechanical, or electrical and involves activation of peripheral sensory nerves. The signal transfer to the ...
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ژورنال
عنوان ژورنال: World Journal of Cardiology
سال: 2015
ISSN: 1949-8462
DOI: 10.4330/wjc.v7.i10.621